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The confidence interval for the AUC(0-τ) comparison was outside the standard range of 80%-125% (reported 90% eszopiclone CI 71 .
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This study was conducted at steady-state in healthy subjects and used eszopiclone a validated chiral bioanalytical method (LOQ ~ 1 ng/mL) .
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Blood samples were obtained for plasma concentration assays of (S)- zopiclone, (S)-desmethylzopiclone, N-oxide-zopiclone, (R)-Zopiclone and (R)-desmethylzopiclone following single and multiple dose eszopiclone administration .
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